family history. Around 10% are familial and linked to inherited genetic variants. ([NINDS][
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3])
Scientists have identified multiple genes associated with ALS, including:
C9orf72
SOD1
FUS
TARDBP
Research continues into how genetics, cellular processes, and environmental factors contribute to the disease.
How Is ALS Diagnosed?
There is no single simple blood test that confirms ALS.
Diagnosis generally involves:
Detailed neurological examination
Medical history
Electromyography (EMG)
Nerve-conduction studies
Blood tests
Imaging when appropriate
Other testing to exclude similar conditions
ALS can be difficult to diagnose early because several neurological and muscular diseases can mimic its symptoms. ([Mayo Clinic][2])
Conditions That Can Mimic ALS
Progressive weakness, twitching, or speech problems can occur with many conditions other than ALS.
Doctors may consider possibilities such as:
Peripheral neuropathy
Cervical spine problems
Myasthenia gravis
Multiple sclerosis
Vitamin deficiencies
Thyroid disorders
Certain muscular diseases
Other motor-neuron disorders
This is why searching symptoms online cannot provide a reliable diagnosis.
When Should You See a Doctor?
Arrange medical evaluation if
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you develop progressive and unexplained symptoms such as:Increasing weakness in one arm or leg
Repeated unexplained falls
